Asthma, characterized by airway hyperresponsiveness, inflammation and remodeling, is a
chronic airway disease with complex etiology. Severe asthma is characterized by frequent
exacerbations and poor therapeutic response to conventional asthma therapy. A clear
understanding of cellular and molecular mechanisms of asthma is critical for the discovery of
novel targets for optimal therapeutic control of asthma. Metabolomics is emerging as a
powerful tool to elucidate novel disease mechanisms in a variety of diseases. In this review …