Telomerase activity is critical for cancer cells to provide unrestricted proliferation and cellular
immortality through maintaining telomeres. Telomerase enzymatic activity is regulatable at
the level of DNA, mRNA, post translational modifications, cellular transport and enzyme
assembly. More recent studies confirm the interaction of the telomerase with various
intracellular signaling pathways including PI3K/AKT/mTOR, NF-κB and Wnt/β-catenin which
mainly participating in inflammation, epithelial to mesenchymal transition (EMT) and tumor …