Metabolomics in asthma: where do we stand?
H Pité, M Morais-Almeida… - Current opinion in …, 2018 - journals.lww.com
H Pité, M Morais-Almeida, SM Rocha
Current opinion in pulmonary medicine, 2018•journals.lww.comMetabolomics has provided unique and novel insights into asthma profiling at the molecular
level. Current challenges include procedures standardization and control of potentially
confounding variables for external validation. Point-of-care technology developments bring
metabolomics closer to clinical practice. In addition to biomarkers identification, relating
metabolites to their biologic role will serve as critical foundations for understanding the
biology underpinning asthma heterogeneity and for specific-targeted therapies.
level. Current challenges include procedures standardization and control of potentially
confounding variables for external validation. Point-of-care technology developments bring
metabolomics closer to clinical practice. In addition to biomarkers identification, relating
metabolites to their biologic role will serve as critical foundations for understanding the
biology underpinning asthma heterogeneity and for specific-targeted therapies.
Summary
Metabolomics has provided unique and novel insights into asthma profiling at the molecular level. Current challenges include procedures standardization and control of potentially confounding variables for external validation. Point-of-care technology developments bring metabolomics closer to clinical practice. In addition to biomarkers identification, relating metabolites to their biologic role will serve as critical foundations for understanding the biology underpinning asthma heterogeneity and for specific-targeted therapies.
Lippincott Williams & Wilkins