Autoantibody-positive healthy individuals with lower lupus risk display a unique immune endotype
S Slight-Webb, M Smith, A Bylinska, S Macwana… - Journal of Allergy and …, 2020 - Elsevier
Background Autoimmune diseases comprise a spectrum of illnesses and are on the rise
worldwide. Although antinuclear antibodies (ANAs) are detected in many autoimmune
diseases, up to 20% of healthy women are ANA-positive (ANA+) and most will never
develop clinical symptoms. Furthermore, disease transition is higher among ANA+ African
Americans compared with ANA+ European Americans. Objective We sought to determine
the immune features that might define and prevent transition to clinical autoimmunity in …
worldwide. Although antinuclear antibodies (ANAs) are detected in many autoimmune
diseases, up to 20% of healthy women are ANA-positive (ANA+) and most will never
develop clinical symptoms. Furthermore, disease transition is higher among ANA+ African
Americans compared with ANA+ European Americans. Objective We sought to determine
the immune features that might define and prevent transition to clinical autoimmunity in …