[HTML][HTML] Proteomic differences between hepatocellular carcinoma and nontumorous liver tissue investigated by a combined gel-based and label-free quantitative …
DA Megger, T Bracht, M Kohl, M Ahrens… - Molecular & Cellular …, 2013 - ASBMB
Proteomics-based clinical studies have been shown to be promising strategies for the
discovery of novel biomarkers of a particular disease. Here, we present a study of
hepatocellular carcinoma (HCC) that combines complementary two-dimensional difference
in gel electrophoresis (2D-DIGE) and liquid chromatography (LC-MS)-based approaches of
quantitative proteomics. In our proteomic experiments, we analyzed a set of 14 samples (7×
HCC versus 7× nontumorous liver tissue) with both techniques. Thereby we identified 573 …
discovery of novel biomarkers of a particular disease. Here, we present a study of
hepatocellular carcinoma (HCC) that combines complementary two-dimensional difference
in gel electrophoresis (2D-DIGE) and liquid chromatography (LC-MS)-based approaches of
quantitative proteomics. In our proteomic experiments, we analyzed a set of 14 samples (7×
HCC versus 7× nontumorous liver tissue) with both techniques. Thereby we identified 573 …