[HTML][HTML] Epidermal growth factor receptor (EGFR) signaling regulates global metabolic pathways in EGFR-mutated lung adenocarcinoma

H Makinoshima, M Takita, S Matsumoto… - Journal of Biological …, 2014 - ASBMB
Genetic mutations in tumor cells cause several unique metabolic phenotypes that are critical
for cancer cell proliferation. Mutations in the tyrosine kinase epidermal growth factor receptor
(EGFR) induce oncogenic addiction in lung adenocarcinoma (LAD). However, the linkage
between oncogenic mutated EGFR and cancer cell metabolism has not yet been clearly
elucidated. Here we show that EGFR signaling plays an important role in aerobic glycolysis
in EGFR-mutated LAD cells. EGFR-tyrosine kinase inhibitors (TKIs) decreased lactate …