Sulfur amino acid metabolism: pathways for production and removal of homocysteine and cysteine
MH Stipanuk - Annu. Rev. Nutr., 2004 - annualreviews.org
▪ Abstract Tissue concentrations of both homocysteine (Hcy) and cysteine (Cys) are
maintained at low levels by regulated production and efficient removal of these thiols. The
regulation of the metabolism of methionine and Cys is discussed from the standpoint of
maintaining low levels of Hcy and Cys while, at the same time, ensuring an adequate supply
of these thiols for their essential functions. S-Adenosylmethionine coordinately regulates the
flux through remethylation and transsulfuration, and glycine N-methyltransferase regulates …
maintained at low levels by regulated production and efficient removal of these thiols. The
regulation of the metabolism of methionine and Cys is discussed from the standpoint of
maintaining low levels of Hcy and Cys while, at the same time, ensuring an adequate supply
of these thiols for their essential functions. S-Adenosylmethionine coordinately regulates the
flux through remethylation and transsulfuration, and glycine N-methyltransferase regulates …