Fatty acid synthase and cancer: new application of an old pathway

FP Kuhajda - Cancer research, 2006 - AACR
FP Kuhajda
Cancer research, 2006AACR
Fatty acid synthase (FAS), the sole mammalian enzyme capable of de novo fatty acid
synthesis, is highly expressed in most human carcinomas. FAS is associated with poor
prognosis in breast and prostate cancer, is elaborated into the blood of cancer patients, and
its inhibition is selectively cytotoxic to human cancer cells. Thus, FAS and fatty acid
metabolism in cancer has become a focus for the potential diagnosis and treatment of
cancer.(Cancer Res 2006; 66 (12): 5977-80)
Abstract
Fatty acid synthase (FAS), the sole mammalian enzyme capable of de novo fatty acid synthesis, is highly expressed in most human carcinomas. FAS is associated with poor prognosis in breast and prostate cancer, is elaborated into the blood of cancer patients, and its inhibition is selectively cytotoxic to human cancer cells. Thus, FAS and fatty acid metabolism in cancer has become a focus for the potential diagnosis and treatment of cancer. (Cancer Res 2006; 66(12): 5977-80)
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