Cholesterol and the development of clear-cell renal carcinoma
HA Drabkin, RM Gemmill - Current opinion in pharmacology, 2012 - Elsevier
The majority of kidney cancers are clear-cell carcinomas (ccRCC), characterized by the
accumulation of cholesterol, cholesterol esters, other neutral lipids and glycogen. Rather
than being a passive bystander, the clear-cell phenotype is suggested to be a biomarker of
deregulated cholesterol and lipid biosynthesis, which plays an important role in
development of the disease. One clue to this relationship has come from the elucidation of
the hereditary kidney cancer gene, TRC8, which functions partly to degrade key regulators …
accumulation of cholesterol, cholesterol esters, other neutral lipids and glycogen. Rather
than being a passive bystander, the clear-cell phenotype is suggested to be a biomarker of
deregulated cholesterol and lipid biosynthesis, which plays an important role in
development of the disease. One clue to this relationship has come from the elucidation of
the hereditary kidney cancer gene, TRC8, which functions partly to degrade key regulators …