Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation
C Guiducci, G Ott, JH Chan, E Damon… - Journal of Experimental …, 2006 - rupress.org
C Guiducci, G Ott, JH Chan, E Damon, C Calacsan, T Matray, KD Lee, RL Coffman, FJ Barrat
Journal of Experimental Medicine, 2006•rupress.orgRESULTS Multimeric display of TLR9 ligands correlates with their ability to induce IFN-𝛂
production from human PDCs Three classes of ISS (CpG-A,-B,-C) with very different
biological activities on enriched human PDCs have been described. CpG-A and CpG-C ISS
can induce high levels of IFN-α, whereas CpG-B are unable to do so. However, when CpG-B
are mixed with PMXB, the ODN is complexed into
production from human PDCs Three classes of ISS (CpG-A,-B,-C) with very different
biological activities on enriched human PDCs have been described. CpG-A and CpG-C ISS
can induce high levels of IFN-α, whereas CpG-B are unable to do so. However, when CpG-B
are mixed with PMXB, the ODN is complexed into
RESULTS Multimeric display of TLR9 ligands correlates with their ability to induce IFN-𝛂 production from human PDCs
Three classes of ISS (CpG-A,-B,-C) with very different biological activities on enriched human PDCs have been described. CpG-A and CpG-C ISS can induce high levels of IFN-α, whereas CpG-B are unable to do so. However, when CpG-B are mixed with PMXB, the ODN is complexed into
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