Differential signaling by CpG DNA in DCs and B cells: not just TLR9
D Verthelyi, RA Zeuner - Trends in immunology, 2003 - cell.com
D Verthelyi, RA Zeuner
Trends in immunology, 2003•cell.comAbstract CpG-containing oligodeoxynucleotides (CpG ODNs) act on Toll-like receptor 9
(TLR9) that is expressed on B cells and plasmacytoid dendritic cells (pDCs) to stimulate the
innate immune system, however, different types of CpG ODNs induce distinct responses.
Recent papers suggest some CpG ODNs could require a second receptor or cofactor to
signal. The different signaling complexes assembled might impact on the affinity with which
CpG ODNs signal to TLR9 or activate additional pathways that lead to distinct immune …
(TLR9) that is expressed on B cells and plasmacytoid dendritic cells (pDCs) to stimulate the
innate immune system, however, different types of CpG ODNs induce distinct responses.
Recent papers suggest some CpG ODNs could require a second receptor or cofactor to
signal. The different signaling complexes assembled might impact on the affinity with which
CpG ODNs signal to TLR9 or activate additional pathways that lead to distinct immune …
Abstract
CpG-containing oligodeoxynucleotides (CpG ODNs) act on Toll-like receptor 9 (TLR9) that is expressed on B cells and plasmacytoid dendritic cells (pDCs) to stimulate the innate immune system, however, different types of CpG ODNs induce distinct responses. Recent papers suggest some CpG ODNs could require a second receptor or cofactor to signal. The different signaling complexes assembled might impact on the affinity with which CpG ODNs signal to TLR9 or activate additional pathways that lead to distinct immune responses.
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