Cellular and molecular mechanisms of chronic obstructive pulmonary disease
PJ Barnes - Clinics in chest medicine, 2014 - chestmed.theclinics.com
Chronic obstructive pulmonary disease (COPD) involves chronic inflammation of the lung,
particularly in peripheral airways and parenchyma, which increases during acute
exacerbations. It is also associated with systemic inflammation, which may contribute to or
worsen several comorbidities and may be derived from overspill from the peripheral lung. 1
It is important to understand the nature of this inflammatory response in order to develop
effective antiinflammatory treatments for COPD in the future. 2
particularly in peripheral airways and parenchyma, which increases during acute
exacerbations. It is also associated with systemic inflammation, which may contribute to or
worsen several comorbidities and may be derived from overspill from the peripheral lung. 1
It is important to understand the nature of this inflammatory response in order to develop
effective antiinflammatory treatments for COPD in the future. 2
