[HTML][HTML] Cloning and characterization of COX18, ASaccharomyces cerevisiae PET gene required for the assembly of cytochrome oxidase

RL Souza, NS Green-Willms, TD Fox… - Journal of Biological …, 2000 - ASBMB
Nuclear mutants of Saccharomyces cerevisiae assigned to complementation group G34 are
respiratory-deficient and lack cytochrome oxidase activity and the characteristic spectral
peaks of cytochromes a anda 3. The corresponding gene was cloned by complementation,
sequenced, and identified as reading frame YGR062C on chromosome VII. This gene was
named COX18. TheCOX18 gene product is a polypeptide of 316 amino acids with a putative
amino-terminal mitochondrial targeting sequence and predicted transmembrane domains …