[HTML][HTML] Application and pharmacological mechanism of methotrexate in rheumatoid arthritis
Z Zhao, Z Hua, X Luo, Y Li, L Yu, M Li, C Lu… - Biomedicine & …, 2022 - Elsevier
Z Zhao, Z Hua, X Luo, Y Li, L Yu, M Li, C Lu, T Zhao, Y Liu
Biomedicine & Pharmacotherapy, 2022•ElsevierMethotrexate (MTX) has been used for the treatment of rheumatoid arthritis (RA) for about
forty years and to date MTX remains the part of global standard of treatment for RA. The
efficacy of MTX in RA is the result of multiple mechanisms of action. In order to summarize
the possible pharmacological mechanisms of MTX in the treatment of RA, this review will
elaborate on folate antagonism, promotion of adenosine accumulation, regulation of
inflammatory signaling pathways, bone protection and maintenance of immune system …
forty years and to date MTX remains the part of global standard of treatment for RA. The
efficacy of MTX in RA is the result of multiple mechanisms of action. In order to summarize
the possible pharmacological mechanisms of MTX in the treatment of RA, this review will
elaborate on folate antagonism, promotion of adenosine accumulation, regulation of
inflammatory signaling pathways, bone protection and maintenance of immune system …
Abstract
Methotrexate (MTX) has been used for the treatment of rheumatoid arthritis (RA) for about forty years and to date MTX remains the part of global standard of treatment for RA. The efficacy of MTX in RA is the result of multiple mechanisms of action. In order to summarize the possible pharmacological mechanisms of MTX in the treatment of RA, this review will elaborate on folate antagonism, promotion of adenosine accumulation, regulation of inflammatory signaling pathways, bone protection and maintenance of immune system function.
Elsevier
