Galantamine: a review of its use in Alzheimer's disease
LJ Scott, KL Goa - Drugs, 2000 - Springer
LJ Scott, KL Goa
Drugs, 2000•SpringerCurrently, acetylcholinesterase (AChE) inhibitors are the most promising class of drugs for
the treatment of Alzheimer's disease (AD). Galantamine is a reversible, competitive, tertiary
alkaloid AChE inhibitor. The drug is selective for AChE rather than butyrylcholinesterase. In
addition to inhibition of AChE galantamine interacts allosterically with nicotinic acetylcholine
receptors to potentiate the action of agonists at these receptors.
the treatment of Alzheimer's disease (AD). Galantamine is a reversible, competitive, tertiary
alkaloid AChE inhibitor. The drug is selective for AChE rather than butyrylcholinesterase. In
addition to inhibition of AChE galantamine interacts allosterically with nicotinic acetylcholine
receptors to potentiate the action of agonists at these receptors.
Summary
Currently, acetylcholinesterase (AChE) inhibitors are the most promising class of drugs for the treatment of Alzheimer’s disease (AD). Galantamine is a reversible, competitive, tertiary alkaloid AChE inhibitor. The drug is selective for AChE rather than butyrylcholinesterase. In addition to inhibition of AChE galantamine interacts allosterically with nicotinic acetylcholine receptors to potentiate the action of agonists at these receptors.
Springer