Skeletal muscle mass and function decline with aging, a process known as sarcopenia,
which restrains posture maintenance, mobility and quality of life in the elderly. Sarcopenia is
also linked to a progressive reduction in the regenerative capacity of the skeletal muscle
stem cells (satellite cells), which are critical for myofiber formation in early life stages and for
sustaining repair in response to muscle damage or trauma. Here we will review the most
recent findings on the causes underlying satellite cell functional decline with aging, and will …