Four-year placebo-controlled trial of docosahexaenoic acid in X-linked retinitis pigmentosa (DHAX trial): a randomized clinical trial
DR Hoffman, DK Hughbanks-Wheaton… - JAMA …, 2014 - jamanetwork.com
Importance X-linked retinitis pigmentosa is a severe inherited retinal degenerative disease
with a frequency of 1 in 100 000 persons. Because no cure is available for this orphan
disease and treatment options are limited, slowing of disease progression would be a
meaningful outcome. Objective To determine whether high-dose docosahexaenoic acid
(DHA), an ω-3 polyunsaturated fatty acid, slows progression of X-linked retinitis pigmentosa
measured by cone electroretinography (ERG). Design, Setting, and Participants A 4-year …
with a frequency of 1 in 100 000 persons. Because no cure is available for this orphan
disease and treatment options are limited, slowing of disease progression would be a
meaningful outcome. Objective To determine whether high-dose docosahexaenoic acid
(DHA), an ω-3 polyunsaturated fatty acid, slows progression of X-linked retinitis pigmentosa
measured by cone electroretinography (ERG). Design, Setting, and Participants A 4-year …
