The role of CTGF in diabetic retinopathy
I Klaassen, RJ van Geest, EJ Kuiper… - Experimental Eye …, 2015 - Elsevier
Connective tissue growth factor (CTGF, CCN2) contributes to fibrotic responses in diabetic
retinopathy, both before clinical manifestations occur in the pre-clinical stage of diabetic
retinopathy (PCDR) and in proliferative diabetic retinopathy (PDR), the late clinical stage of
the disease. CTGF is a secreted protein that modulates the actions of many growth factors
and extracellular matrix (ECM) proteins, leading to tissue reorganization, such as ECM
formation and remodeling, basal lamina (BL) thickening, pericyte apoptosis, angiogenesis …
retinopathy, both before clinical manifestations occur in the pre-clinical stage of diabetic
retinopathy (PCDR) and in proliferative diabetic retinopathy (PDR), the late clinical stage of
the disease. CTGF is a secreted protein that modulates the actions of many growth factors
and extracellular matrix (ECM) proteins, leading to tissue reorganization, such as ECM
formation and remodeling, basal lamina (BL) thickening, pericyte apoptosis, angiogenesis …