The dual effect of isoproterenol on insulin release is suppressed in pancreatic islets from hypothalamic obese rats
AC Marçal, S Grassiolli, DN da Rocha, MA Puzzi… - Endocrine, 2006 - Springer
AC Marçal, S Grassiolli, DN da Rocha, MA Puzzi, C Gravena, DX Scomparin, PCF Mathias
Endocrine, 2006•SpringerHyperinsulinemia in obesity has been attributed to insulin oversecretion by pancreatic beta-
cells. Beta-cells are equipped with cholinergic and adrenergic receptors; whereas overall
acetylcholine action is to potentiate, catecholamines' effect is to inhibit glucoseinduced
insulin release (GIIR) via α 2-adrenoreceptor. However, it has been shown that\-adrenergic
agonists potentiate glucose response. GIIR was studied in pancreatic islets from
hyperinsulinemic adult obese rats, obtained by l-glutamate monosodium (MSG) neonatal …
cells. Beta-cells are equipped with cholinergic and adrenergic receptors; whereas overall
acetylcholine action is to potentiate, catecholamines' effect is to inhibit glucoseinduced
insulin release (GIIR) via α 2-adrenoreceptor. However, it has been shown that\-adrenergic
agonists potentiate glucose response. GIIR was studied in pancreatic islets from
hyperinsulinemic adult obese rats, obtained by l-glutamate monosodium (MSG) neonatal …
Abstract
Hyperinsulinemia in obesity has been attributed to insulin oversecretion by pancreatic beta-cells. Beta-cells are equipped with cholinergic and adrenergic receptors; whereas overall acetylcholine action is to potentiate, catecholamines' effect is to inhibit glucoseinduced insulin release (GIIR) via α2-adrenoreceptor. However, it has been shown that \-adrenergic agonists potentiate glucose response. GIIR was studied in pancreatic islets from hyperinsulinemic adult obese rats, obtained by l-glutamate monosodium (MSG) neonatal treatment. Islets from MSG-rats were more glucose responsive than control ones. Isoproterenol, a \-adrenergic agonist, inhibited the GIIR in islets from MSG-obese rats. Results indicate that MSG treatment causes alteration on function of beta-cell adrenoceptors.
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