Keratin hypersumoylation alters filament dynamics and is a marker for human liver disease and keratin mutation
NT Snider, SVW Weerasinghe, JA Iñiguez-Lluhí… - Journal of Biological …, 2011 - jbc.org
Keratin polypeptide 8 (K8) associates noncovalently with its partners K18 and/or K19 to form
the intermediate filament cytoskeleton of hepatocytes and other simple-type epithelial cells.
Human K8, K18, and K19 variants predispose to liver disease, whereas site-specific keratin
phosphorylation confers hepatoprotection. Because stress-induced protein phosphorylation
regulates sumoylation, we hypothesized that keratins are sumoylated in an injury-dependent
manner and that keratin sumoylation is an important regulatory modification. We …
the intermediate filament cytoskeleton of hepatocytes and other simple-type epithelial cells.
Human K8, K18, and K19 variants predispose to liver disease, whereas site-specific keratin
phosphorylation confers hepatoprotection. Because stress-induced protein phosphorylation
regulates sumoylation, we hypothesized that keratins are sumoylated in an injury-dependent
manner and that keratin sumoylation is an important regulatory modification. We …
