[CITATION][C] A novel family ofras-binding domains

CP Ponting, DR Benjamin - Trends in biochemical sciences, 1996 - Elsevier
CP Ponting, DR Benjamin
Trends in biochemical sciences, 1996Elsevier
CIDs include the regulated degradation of proteins, the control of vesicle fusion and the
movement of proteins between intracellular compartments. Gaining control of these basic
mechanisms might also provide a method to control the production or activity of many
proteins for therapeutic purposes 39. Perhaps the most significant outcome of the early
results with CIDs and chimeric proteins is that they demonstrate how one could feasibly
design a new class of CIDs that induces the dimerization or association of normal, non …
CIDs include the regulated degradation of proteins, the control of vesicle fusion and the movement of proteins between intracellular compartments. Gaining control of these basic mechanisms might also provide a method to control the production or activity of many proteins for therapeutic purposes 39. Perhaps the most significant outcome of the early results with CIDs and chimeric proteins is that they demonstrate how one could feasibly design a new class of CIDs that induces the dimerization or association of normal, non-chimeric molecules in cells. This would involve protein structure-based combinatorial chemistry to design agents that bind critical cellular proteins (such as receptors) followed by chemical dimerization of these agents; and finally optimization of these dimeric reagents using biological assays. Such a new class of molecules might prove effective substitutes for expensive, and difficult to administer, protein growth factors and cytokines. In addition, CIDs that control intracellular, non-engineered proteins should allow control of intracellular signaling processes for therapeutic or experimental purposes.
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