Claudin upregulation in ovarian carcinoma effusions is associated with poor survival
L Kleinberg, A Holth, CG Trope, R Reich, B Davidson - Human pathology, 2008 - Elsevier
Claudins are tight junction proteins that are highly expressed in ovarian carcinoma (OC).
The objective of this study was to analyze the anatomic site-related expression and clinical
role of claudins in OC. Effusions (n= 218), corresponding primary tumors (n= 81), and solid
metastases (n= 164)(total= 463 tumors) were immunostained for claudin-1, claudin-3,
claudin-4, and claudin-7. Results were analyzed for association with anatomic site,
clinicopathologic parameters, and survival. All 4 claudins were expressed in> 85% of tumors …
The objective of this study was to analyze the anatomic site-related expression and clinical
role of claudins in OC. Effusions (n= 218), corresponding primary tumors (n= 81), and solid
metastases (n= 164)(total= 463 tumors) were immunostained for claudin-1, claudin-3,
claudin-4, and claudin-7. Results were analyzed for association with anatomic site,
clinicopathologic parameters, and survival. All 4 claudins were expressed in> 85% of tumors …