Tight junction associated proteins are key molecular components governing cellular
adhesion, polarity and glandular differentiation. Tight junction proteins also play critical roles
in cellular proliferation and neoplastic pathways via their functions as couplers of the
extracellular milieu to intracellular signaling pathways and the cytoskeleton. Neoplastic cells
frequently exhibit structural and functional deficiencies in the tight junction. The purpose of
this study was to determine the pattern of expression and prognostic value of four tight …