[HTML][HTML] A three-dimensional microenvironment alters protein expression and chemosensitivity of epithelial ovarian cancer cells in vitro
JM Lee, P Mhawech-Fauceglia, N Lee… - Laboratory …, 2013 - Elsevier
For many cancers, there is a real need for more effective therapies. Although many drugs
show promising results in vitro, most fail to translate into an in vivo model system, and only∼
5% show anti-tumor activity in clinical trials. It remains a significant challenge to accurately
replicate in vitro the complex in vivo microenvironment in which cancers thrive, but this will
be key to increasing the success of translating novel therapies into clinical practice. Three-
dimensional (3D) cell culture models may better mimic primary tumors in vivo than traditional …
show promising results in vitro, most fail to translate into an in vivo model system, and only∼
5% show anti-tumor activity in clinical trials. It remains a significant challenge to accurately
replicate in vitro the complex in vivo microenvironment in which cancers thrive, but this will
be key to increasing the success of translating novel therapies into clinical practice. Three-
dimensional (3D) cell culture models may better mimic primary tumors in vivo than traditional …