[HTML][HTML] Lysophosphatidylcholine as an effector of fatty acid-induced insulin resistance [S]
MS Han, YM Lim, W Quan, JR Kim, KW Chung… - Journal of lipid …, 2011 - ASBMB
The mechanism of FFA-induced insulin resistance is not fully understood. We have
searched for effector molecules (s) in FFA-induced insulin resistance. Palmitic acid (PA) but
not oleic acid (OA) induced insulin resistance in L6 myotubes through C-Jun N-terminal
kinase (JNK) and insulin receptor substrate 1 (IRS-1) Ser307 phosphorylation. Inhibitors of
ceramide synthesis did not block insulin resistance by PA. However, inhibition of the
conversion of PA to lysophosphatidylcholine (LPC) by calcium-independent phospholipase …
searched for effector molecules (s) in FFA-induced insulin resistance. Palmitic acid (PA) but
not oleic acid (OA) induced insulin resistance in L6 myotubes through C-Jun N-terminal
kinase (JNK) and insulin receptor substrate 1 (IRS-1) Ser307 phosphorylation. Inhibitors of
ceramide synthesis did not block insulin resistance by PA. However, inhibition of the
conversion of PA to lysophosphatidylcholine (LPC) by calcium-independent phospholipase …