Subliminal Message: Outer Retinal Tubulations Resembling Mitochondria in Maternally Inherited Diabetes and Deafness

IC Han, DB Critser, EM Stone - Ophthalmology Retina, 2020 - ophthalmologyretina.org
A 43-year-old woman with diabetes mellitus was referred for presumed pattern dystrophy
resulting from perifoveal islands of atrophy (A, right eye). Structural en face swept-source
OCT (C) through the outer retina (avascular slab) demonstrated oblong lesions with
invaginated borders, reminiscent of mitochondria with cristae. Line scans (B, D) showed that
the lesion edges corresponded to scrolled external limiting membrane (D, arrows) and that
the invaginations correlated to outer retinal tubulations (D, asterisks). Sequencing of pattern …