Selection analysis identifies clusters of unusual mutational changes in omicron lineage BA. 1 that likely impact spike function
Among the 30 nonsynonymous nucleotide substitutions in the Omicron S-gene are 13 that
have only rarely been seen in other SARS-CoV-2 sequences. These mutations cluster within
three functionally important regions of the S-gene at sites that will likely impact (1)
interactions between subunits of the Spike trimer and the predisposition of subunits to shift
from down to up configurations,(2) interactions of Spike with ACE2 receptors, and (3) the
priming of Spike for membrane fusion. We show here that, based on both the rarity of these …
have only rarely been seen in other SARS-CoV-2 sequences. These mutations cluster within
three functionally important regions of the S-gene at sites that will likely impact (1)
interactions between subunits of the Spike trimer and the predisposition of subunits to shift
from down to up configurations,(2) interactions of Spike with ACE2 receptors, and (3) the
priming of Spike for membrane fusion. We show here that, based on both the rarity of these …
Selection analysis identifies unusual clustered mutational changes in Omicron lineage BA. 1 that likely impact Spike function
Among the 30 non-synonymous nucleotide substitutions in the Omicron S-gene are 13 that
have only rarely been seen in other SARS-CoV-2 sequences. These mutations cluster within
three functionally important regions of the S-gene at sites that will likely impact (i)
interactions between subunits of the Spike trimer and the predisposition of subunits to shift
from down to up configurations,(ii) interactions of Spike with ACE2 receptors, and (iii) the
priming of Spike for membrane fusion. We show here that, based on both the rarity of these …
have only rarely been seen in other SARS-CoV-2 sequences. These mutations cluster within
three functionally important regions of the S-gene at sites that will likely impact (i)
interactions between subunits of the Spike trimer and the predisposition of subunits to shift
from down to up configurations,(ii) interactions of Spike with ACE2 receptors, and (iii) the
priming of Spike for membrane fusion. We show here that, based on both the rarity of these …
