[HTML][HTML] Serum albumin acts as a shuttle to enhance cholesterol efflux from cells [S]

S Sankaranarayanan, M de la Llera-Moya… - Journal of lipid …, 2013 - ASBMB
An important mechanism contributing to cell cholesterol efflux is aqueous transfer in which
cholesterol diffuses from cells into the aqueous phase and becomes incorporated into an
acceptor particle. Some compounds can enhance diffusion by acting as shuttles transferring
cholesterol to cholesterol acceptors, which act as cholesterol sinks. We have examined
whether particles in serum can enhance cholesterol efflux by acting as shuttles. This task
was accomplished by incubating radiolabeled J774 cells with increasing concentrations of …