Apolipoprotein E and the apolipoprotein E-deficient mouse

AS Plump, JL Breslow - Annual review of nutrition, 1995 - annualreviews.org
AS Plump, JL Breslow
Annual review of nutrition, 1995annualreviews.org
Apolipoprotein E (apoE) is one of several lipoprotein transfer genes. A primary function of
this protein is the mediation of receptor-mediated lipoprotein removal from the blood.
Several studies have demonstrated that genetic variation at the apoE locus is associated
with an increased risk of developing atherosclerosis, and recent studies implicate this same
genetic variation in determining susceptibility to Alzheimer's disease. An apoE-deficient
mouse has been created to further understand the role of apoE in these areas. This review …
Apolipoprotein E (apoE) is one of several lipoprotein transfer genes. A primary function of this protein is the mediation of receptor-mediated lipoprotein removal from the blood. Several studies have demonstrated that genetic variation at the apoE locus is associated with an increased risk of developing atherosclerosis, and recent studies implicate this same genetic variation in determining susceptibility to Alzheimer's disease. An apoE-deficient mouse has been created to further understand the role of apoE in these areas. This review briefly discussed the biological and clinical importance of this protein and describes the early experiments performed in the apoE-deficient mouse.
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