CD19 controls Toll-like receptor 9 responses in human B cells
H Morbach, JN Schickel… - Journal of Allergy and …, 2016 - Elsevier
Background CD19 is a B cell–specific molecule that serves as a major costimulatory
molecule for amplifying B-cell receptor (BCR) responses. Biallelic CD19 gene mutations
cause common variable immunodeficiency in human subjects. BCR-and Toll-like receptor
(TLR) 9–induced B-cell responses are impaired in most patients with common variable
immunodeficiency. Objective We sought to analyze whether CD19 is required for TLR9
function in human B cells. Methods Expression of surface activation markers was assessed …
molecule for amplifying B-cell receptor (BCR) responses. Biallelic CD19 gene mutations
cause common variable immunodeficiency in human subjects. BCR-and Toll-like receptor
(TLR) 9–induced B-cell responses are impaired in most patients with common variable
immunodeficiency. Objective We sought to analyze whether CD19 is required for TLR9
function in human B cells. Methods Expression of surface activation markers was assessed …
