Hormonal regulation of NK cell cytotoxic activity
SV Shirshev, IV Nekrasova, OL Gorbunova… - Doklady Biological …, 2017 - Springer
SV Shirshev, IV Nekrasova, OL Gorbunova, EG Orlova
Doklady Biological Sciences, 2017•SpringerThe effects of chorionic gonadotropin, estriol (E 3), leptin, ghrelin, and kisspeptin on the
intracellular expression of perforin, granzyme A, and granzyme B was studied in separated
NK cells. All studied hormones except E 3 are could modulate the expression of cytotoxic
enzymes in NK cells by suppression of the expression of the most active proapoptotic
agents, resulting in increased expression of granzyme A, which is typical of the decidual
subpopulation of these lymphocytes.
intracellular expression of perforin, granzyme A, and granzyme B was studied in separated
NK cells. All studied hormones except E 3 are could modulate the expression of cytotoxic
enzymes in NK cells by suppression of the expression of the most active proapoptotic
agents, resulting in increased expression of granzyme A, which is typical of the decidual
subpopulation of these lymphocytes.
Abstract
The effects of chorionic gonadotropin, estriol (E3), leptin, ghrelin, and kisspeptin on the intracellular expression of perforin, granzyme A, and granzyme B was studied in separated NK cells. All studied hormones except E3 are could modulate the expression of cytotoxic enzymes in NK cells by suppression of the expression of the most active proapoptotic agents, resulting in increased expression of granzyme A, which is typical of the decidual subpopulation of these lymphocytes.
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