Microglial microRNAs mediate sex-specific responses to tau pathology
Nature neuroscience, 2020•nature.com
Sex is a key modifier of neurological disease outcomes. Microglia are implicated in
neurological diseases and modulated by microRNAs, but it is unknown whether microglial
microRNAs have sex-specific influences on disease. We show in mice that microglial
microRNA expression differs in males and females and that loss of microRNAs leads to sex-
specific changes in the microglial transcriptome and tau pathology. These findings suggest
that microglial microRNAs influence tau pathogenesis in a sex-specific manner.
neurological diseases and modulated by microRNAs, but it is unknown whether microglial
microRNAs have sex-specific influences on disease. We show in mice that microglial
microRNA expression differs in males and females and that loss of microRNAs leads to sex-
specific changes in the microglial transcriptome and tau pathology. These findings suggest
that microglial microRNAs influence tau pathogenesis in a sex-specific manner.
Abstract
Sex is a key modifier of neurological disease outcomes. Microglia are implicated in neurological diseases and modulated by microRNAs, but it is unknown whether microglial microRNAs have sex-specific influences on disease. We show in mice that microglial microRNA expression differs in males and females and that loss of microRNAs leads to sex-specific changes in the microglial transcriptome and tau pathology. These findings suggest that microglial microRNAs influence tau pathogenesis in a sex-specific manner.
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