[HTML][HTML] Conditional ablation of the heparan sulfate-synthesizing enzyme Ext1 leads to dysregulation of bone morphogenic protein signaling and severe skeletal …

Y Matsumoto, K Matsumoto, F Irie, J Fukushi… - Journal of Biological …, 2010 - ASBMB
Increasing evidence indicates that heparan sulfate (HS) is an integral component of many
morphogen signaling pathways. However, its mechanisms of action appear to be diverse,
depending on the type of morphogen and the developmental contexts. To define the function
of HS in skeletal development, we conditionally ablated Ext1, which encodes an essential
glycosyltransferase for HS synthesis, in limb bud mesenchyme using the Prx1-Cre
transgene. These conditional Ext1 mutant mice display severe limb skeletal defects …