The pathogenesis of multiple exostosis has been controversial with many theories put
forward including the structural/mechanical theory, which emphasizes that the
osteochondroma arises in the displaced growth plate cartilage penetrating a defective
periosteum. Recently, molecular genetics has offered the neoplastic model with tumor
suppressor genes implicated in the development and pathogenesis of exostosis. In this
study, we demonstrated the spectrum of histological abnormalities in the developing …