Poly (ADP-Ribose) polymerase promotes cardiac remodeling, contractile failure, and translocation of apoptosis-inducing factor in a murine experimental model of …
CY Xiao, M Chen, Z Zsengellér, H Li, L Kiss… - The Journal of …, 2005 - Elsevier
Oxidant stress-induced activation of poly (ADP-ribose) polymerase (PARP) plays a role in
the pathogenesis of various cardiovascular diseases. We have now investigated the role of
PARP in the process of cardiac remodeling and heart failure in a mouse model of heart
failure induced by transverse aortic constriction (banding). The catalytic activity of PARP was
inhibited by the potent isoindolinone-based PARP inhibitor INO-1001 or by PARP-1 genetic
deficiency. PARP inhibition prevented the pressure overload-induced decrease in cardiac …
the pathogenesis of various cardiovascular diseases. We have now investigated the role of
PARP in the process of cardiac remodeling and heart failure in a mouse model of heart
failure induced by transverse aortic constriction (banding). The catalytic activity of PARP was
inhibited by the potent isoindolinone-based PARP inhibitor INO-1001 or by PARP-1 genetic
deficiency. PARP inhibition prevented the pressure overload-induced decrease in cardiac …
