Panretinal photocoagulation vs intravitreous ranibizumab for proliferative diabetic retinopathy: a randomized clinical trial

JG Gross, AR Glassman, LM Jampol, S Inusah… - Jama, 2015 - jamanetwork.com
Importance Panretinal photocoagulation (PRP) is the standard treatment for reducing severe
visual loss from proliferative diabetic retinopathy. However, PRP can damage the retina,
resulting in peripheral vision loss or worsening diabetic macular edema (DME). Objective To
evaluate the noninferiority of intravitreous ranibizumab compared with PRP for visual acuity
outcomes in patients with proliferative diabetic retinopathy. Design, Setting, and Participants
Randomized clinical trial conducted at 55 US sites among 305 adults with proliferative …