Central GLP-1 actions on energy metabolism
DA Velásquez, D Beiroa, MJ Vázquez, A Romero… - Vitamins & …, 2010 - Elsevier
Abstract Glucagon-like peptide 1 (GLP-1) is secreted mainly by the intestine in a nutrient-
dependent manner and stimulates glucose-induced insulin secretion, inhibits gastric
emptying, food intake, and glucagon secretion. All these beneficial effects make GLP-1 as a
promising, and currently in the market, drug candidate for the treatment of type 2 diabetes.
More recently, it has been also demonstrated that within the central nervous system, GLP-1
also exerts important metabolic actions inhibiting food intake, increasing insulin secretion …
dependent manner and stimulates glucose-induced insulin secretion, inhibits gastric
emptying, food intake, and glucagon secretion. All these beneficial effects make GLP-1 as a
promising, and currently in the market, drug candidate for the treatment of type 2 diabetes.
More recently, it has been also demonstrated that within the central nervous system, GLP-1
also exerts important metabolic actions inhibiting food intake, increasing insulin secretion …
