Brain GLP‐1 and the regulation of food intake: GLP‐1 action in the brain and its implications for GLP‐1 receptor agonists in obesity treatment
S Trapp, DI Brierley - British Journal of Pharmacology, 2022 - Wiley Online Library
British Journal of Pharmacology, 2022•Wiley Online Library
This review considers the similarities and differences between the physiological systems
regulated by gut‐derived and neuronally produced glucagon‐like peptide 1 (GLP‐1). It
addresses the questions of whether peripheral and central GLP‐1 sources constitute
separate, linked or redundant systems and whether the brain GLP‐1 system consists of
disparate sections or is a homogenous entity. This review also explores the implications of
the answers to these questions for the use of GLP‐1 receptor agonists as anti‐obesity drugs …
regulated by gut‐derived and neuronally produced glucagon‐like peptide 1 (GLP‐1). It
addresses the questions of whether peripheral and central GLP‐1 sources constitute
separate, linked or redundant systems and whether the brain GLP‐1 system consists of
disparate sections or is a homogenous entity. This review also explores the implications of
the answers to these questions for the use of GLP‐1 receptor agonists as anti‐obesity drugs …
This review considers the similarities and differences between the physiological systems regulated by gut‐derived and neuronally produced glucagon‐like peptide 1 (GLP‐1). It addresses the questions of whether peripheral and central GLP‐1 sources constitute separate, linked or redundant systems and whether the brain GLP‐1 system consists of disparate sections or is a homogenous entity. This review also explores the implications of the answers to these questions for the use of GLP‐1 receptor agonists as anti‐obesity drugs.
LINKED ARTICLES
This article is part of a themed issue on GLP1 receptor ligands (BJP 75th Anniversary). To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.4/issuetoc
Wiley Online Library