[HTML][HTML] Expression patterns and function of chromatin protein HMGB2 during mesenchymal stem cell differentiation
N Taniguchi, B Caramés, E Hsu, S Cherqui… - Journal of Biological …, 2011 - ASBMB
The superficial zone (SZ) of articular cartilage is critical in maintaining tissue function and
homeostasis and represents the site of the earliest changes in osteoarthritis (OA). The
expression of chromatin protein HMGB2 is restricted to the SZ, which contains cells
expressing mesenchymal stem cell (MSC) markers. Age-related loss of HMGB2 and gene
deletion are associated with reduced SZ cellularity and early onset OA. This study
addressed HMGB2 expression patterns in MSC and its role during differentiation. HMGB2 …
homeostasis and represents the site of the earliest changes in osteoarthritis (OA). The
expression of chromatin protein HMGB2 is restricted to the SZ, which contains cells
expressing mesenchymal stem cell (MSC) markers. Age-related loss of HMGB2 and gene
deletion are associated with reduced SZ cellularity and early onset OA. This study
addressed HMGB2 expression patterns in MSC and its role during differentiation. HMGB2 …