Carvedilol for children and adolescents with heart failure: a randomized controlled trial
RE Shaddy, MM Boucek, DT Hsu, RJ Boucek… - Jama, 2007 - jamanetwork.com
ContextAlthough β-blockers improve symptoms and survival in adults with heart failure, little
is known about these medications in children and adolescents. ObjectiveTo prospectively
evaluate the effects of carvedilol in children and adolescents with symptomatic systemic
ventricular systolic dysfunction. Design, Setting, and ParticipantsA multicenter, randomized,
double-blind, placebo-controlled study of 161 children and adolescents with symptomatic
systolic heart failure from 26 US centers. In addition to treatment with conventional heart …
is known about these medications in children and adolescents. ObjectiveTo prospectively
evaluate the effects of carvedilol in children and adolescents with symptomatic systemic
ventricular systolic dysfunction. Design, Setting, and ParticipantsA multicenter, randomized,
double-blind, placebo-controlled study of 161 children and adolescents with symptomatic
systolic heart failure from 26 US centers. In addition to treatment with conventional heart …