The mechanisms of nucleotide actions in insulin resistance
K Liu, X Jin, X Zhang, H Lian, J Ye - Journal of Genetics and Genomics, 2022 - Elsevier
Insulin resistance contributes to metabolic disorders in obesity and type 2 diabetes. In
mechanisms of insulin resistance, the roles of glucose, fatty acids, and amino acids have
been extensively documented in literature. However, the activities of nucleotides remain to
be reviewed comprehensively in the regulation of insulin sensitivity. Nucleotides are well
known for their activities in biosynthesis of DNA and RNA as well as their signaling activities
in the form of cAMP and cGAMP. Their activities in insulin resistance are dependent on the …
mechanisms of insulin resistance, the roles of glucose, fatty acids, and amino acids have
been extensively documented in literature. However, the activities of nucleotides remain to
be reviewed comprehensively in the regulation of insulin sensitivity. Nucleotides are well
known for their activities in biosynthesis of DNA and RNA as well as their signaling activities
in the form of cAMP and cGAMP. Their activities in insulin resistance are dependent on the …