Physiology of glymphatic solute transport and waste clearance from the brain
L Zhao, A Tannenbaum, ENTP Bakker… - …, 2022 - journals.physiology.org
L Zhao, A Tannenbaum, ENTP Bakker, H Benveniste
Physiology, 2022•journals.physiology.orgThis review focuses on the physiology of glymphatic solute transport and waste clearance,
using evidence from experimental animal models as well as from human studies. Specific
topics addressed include the biophysical characteristics of fluid and solute transport in the
central nervous system, glymphatic-lymphatic coupling, as well as the role of cerebrospinal
fluid movement for brain waste clearance. We also discuss the current understanding of
mechanisms underlying increased waste clearance during sleep.
using evidence from experimental animal models as well as from human studies. Specific
topics addressed include the biophysical characteristics of fluid and solute transport in the
central nervous system, glymphatic-lymphatic coupling, as well as the role of cerebrospinal
fluid movement for brain waste clearance. We also discuss the current understanding of
mechanisms underlying increased waste clearance during sleep.
This review focuses on the physiology of glymphatic solute transport and waste clearance, using evidence from experimental animal models as well as from human studies. Specific topics addressed include the biophysical characteristics of fluid and solute transport in the central nervous system, glymphatic-lymphatic coupling, as well as the role of cerebrospinal fluid movement for brain waste clearance. We also discuss the current understanding of mechanisms underlying increased waste clearance during sleep.
American Physiological Society