Eotaxin-2/CCL24 and eotaxin-3/CCL26 exert differential profibrogenic effects on human lung fibroblasts
M Kohan, I Puxeddu, R Reich, F Levi-Schaffer… - Annals of Allergy …, 2010 - Elsevier
BACKGROUND: Eotaxin-2/CCL24 and eotaxin-3/CCL26 play an important role in
eosinophil chemotaxis and activation in asthma. We previously demonstrated that
eotaxin/CCL11 is profibrogenic for human lung fibroblasts. The effect of eotaxin-2/CCL24
and eotaxin-3/CCL26 on lung fibroblasts has not yet been investigated. OBJECTIVE: To
evaluate whether eotaxin-2/CCL24 and eotaxin-3/CCL26 modulate fibrotic properties of
lung fibroblasts. METHODS: Fibroblast proliferation was evaluated by means of 3 …
eosinophil chemotaxis and activation in asthma. We previously demonstrated that
eotaxin/CCL11 is profibrogenic for human lung fibroblasts. The effect of eotaxin-2/CCL24
and eotaxin-3/CCL26 on lung fibroblasts has not yet been investigated. OBJECTIVE: To
evaluate whether eotaxin-2/CCL24 and eotaxin-3/CCL26 modulate fibrotic properties of
lung fibroblasts. METHODS: Fibroblast proliferation was evaluated by means of 3 …
