[HTML][HTML] A CCL24-dependent pathway augments eosinophilic airway inflammation in house dust mite-challenged Cd163−/− mice
C Dai, X Yao, EM Gordon, A Barochia, RA Cuento… - Mucosal …, 2016 - Elsevier
CD163 is a macrophage scavenger receptor with anti-inflammatory and pro-inflammatory
functions. Here, we report that alveolar macrophages (AMΦs) from asthmatic subjects had
reduced cell-surface expression of CD163, which suggested that CD163 might modulate the
pathogenesis of asthma. Consistent with this, house dust mite (HDM)-challenged Cd163−/−
mice displayed increases in airway eosinophils and mucous cell metaplasia (MCM). The
increased airway eosinophils and MCM in HDM-challenged Cd163−/− mice were mediated …
functions. Here, we report that alveolar macrophages (AMΦs) from asthmatic subjects had
reduced cell-surface expression of CD163, which suggested that CD163 might modulate the
pathogenesis of asthma. Consistent with this, house dust mite (HDM)-challenged Cd163−/−
mice displayed increases in airway eosinophils and mucous cell metaplasia (MCM). The
increased airway eosinophils and MCM in HDM-challenged Cd163−/− mice were mediated …