Importance Laryngotracheal stenosis (LTS) lacks an ideal animal model to study its unique
wound-healing pathophysiology and the effect of interventions. Objective To present an in
vivo, in situ mouse model of LTS that can be used to investigate its pathophysiology,
mechanisms, and interventions for treatment. Design, Setting, and Subjects Prospective
controlled animal study performed at an academic animal research facility on 87 C57BL/6
mice. Interventions Experimental mice (n= 40) underwent bleomycin-coated wire-brush …