Subglottic stenosis examined as a fibrotic response to airway injury characterized by altered mucosal fibroblast activity
T Singh, VC Sandulache, TD Otteson… - … –Head & Neck …, 2010 - jamanetwork.com
Objective To investigate the association between mucosal fibroblast activity and subglottic
stenosis (SGS) development. Design Prospective study of an animal model of SGS. Setting
Academic research laboratory. Subjects New Zealand white rabbits were assigned to either
the cricothyroidotomy and carbon dioxide laser injury group or the cricothyroidotomy and
silver nitrate injury group. Airways were excised for histologic analysis and the
establishment of primary fibroblast cultures. Lesions from surgical excision of established …
stenosis (SGS) development. Design Prospective study of an animal model of SGS. Setting
Academic research laboratory. Subjects New Zealand white rabbits were assigned to either
the cricothyroidotomy and carbon dioxide laser injury group or the cricothyroidotomy and
silver nitrate injury group. Airways were excised for histologic analysis and the
establishment of primary fibroblast cultures. Lesions from surgical excision of established …