Mito-morphosis: mitochondrial fusion, fission, and cristae remodeling as key mediators of cellular function
L Pernas, L Scorrano - Annual review of physiology, 2016 - annualreviews.org
Permanent residency in the eukaryotic cell pressured the prokaryotic mitochondrial ancestor
to strategize for intracellular living. Mitochondria are able to autonomously integrate and
respond to cellular cues and demands by remodeling their morphology. These processes
define mitochondrial dynamics and inextricably link the fate of the mitochondrion and that of
the host eukaryote, as exemplified by the human diseases that result from mutations in
mitochondrial dynamics proteins. In this review, we delineate the architecture of …
to strategize for intracellular living. Mitochondria are able to autonomously integrate and
respond to cellular cues and demands by remodeling their morphology. These processes
define mitochondrial dynamics and inextricably link the fate of the mitochondrion and that of
the host eukaryote, as exemplified by the human diseases that result from mutations in
mitochondrial dynamics proteins. In this review, we delineate the architecture of …