Loss of mitochondrial function impairs lysosomes
J Demers-Lamarche, G Guillebaud, M Tlili… - Journal of biological …, 2016 - jbc.org
Alterations in mitochondrial function, as observed in neurodegenerative diseases, lead to
disrupted energy metabolism and production of damaging reactive oxygen species. Here,
we demonstrate that mitochondrial dysfunction also disrupts the structure and function of
lysosomes, the main degradation and recycling organelle. Specifically, inhibition of
mitochondrial function, following deletion of the mitochondrial protein AIF, OPA1, or PINK1,
as well as chemical inhibition of the electron transport chain, impaired lysosomal activity and …
disrupted energy metabolism and production of damaging reactive oxygen species. Here,
we demonstrate that mitochondrial dysfunction also disrupts the structure and function of
lysosomes, the main degradation and recycling organelle. Specifically, inhibition of
mitochondrial function, following deletion of the mitochondrial protein AIF, OPA1, or PINK1,
as well as chemical inhibition of the electron transport chain, impaired lysosomal activity and …
