Choriocapillaris evaluation in choroideremia using optical coherence tomography angiography

SS Gao, RC Patel, N Jain, M Zhang… - Biomedical optics …, 2017 - opg.optica.org
SS Gao, RC Patel, N Jain, M Zhang, RG Weleber, D Huang, ME Pennesi, Y Jia
Biomedical optics express, 2017opg.optica.org
The choriocapillaris plays an important role in supporting the metabolic demands of the
retina. Studies of the choriocapillaris in disease states with optical coherence tomography
angiography (OCTA) have proven insightful. However, image artifacts complicate the
identification and quantification of the choriocapillaris in degenerative diseases such as
choroideremia. Here, we demonstrate a supervised machine learning approach to detect
intact choriocapillaris based on training with results from an expert grader. We trained a …
The choriocapillaris plays an important role in supporting the metabolic demands of the retina. Studies of the choriocapillaris in disease states with optical coherence tomography angiography (OCTA) have proven insightful. However, image artifacts complicate the identification and quantification of the choriocapillaris in degenerative diseases such as choroideremia. Here, we demonstrate a supervised machine learning approach to detect intact choriocapillaris based on training with results from an expert grader. We trained a random forest classifier to evaluate en face structural OCT and OCTA information along with spatial image features. Evaluation of the trained classifier using previously unseen data showed good agreement with manual grading.
opg.optica.org