Regulation of hepatic six transmembrane epithelial antigen of prostate 4 (STEAP4) expression by STAT3 and CCAAT/enhancer-binding protein α
P Ramadoss, F Chiappini, M Bilban… - Journal of Biological …, 2010 - jbc.org
STEAP4 is a plasma membrane metalloreductase involved in the transport of iron and
copper. Recently, STEAP4 was implicated in promoting insulin sensitivity by acting in white
adipose tissue to control the production of inflammatory cytokines such as interleukin 6.
Indeed, the loss of STEAP4 expression in mice leads to increased production of
inflammatory cytokines in visceral white adipose tissue and systemic insulin resistance. In
this study, we demonstrate that in mouse liver STEAP4 is produced at significant levels and …
copper. Recently, STEAP4 was implicated in promoting insulin sensitivity by acting in white
adipose tissue to control the production of inflammatory cytokines such as interleukin 6.
Indeed, the loss of STEAP4 expression in mice leads to increased production of
inflammatory cytokines in visceral white adipose tissue and systemic insulin resistance. In
this study, we demonstrate that in mouse liver STEAP4 is produced at significant levels and …
